In Silico Antibacterial Activity of Selected Active Compounds of Cherry Leaf (<i>Muntingia calabura</i>) to <i>Staphylococcus aureus</i>

نویسندگان

چکیده

In addition to physical problems, acne caused by Staphylococcus aureus frequently leads psychological problems as well. As a result, Treatment therapy using antibiotics in the long term and at inappropriate doses increases rate of antibiotic resistance. Alternative treatments can be performed natural ingredients, such cherry leaves ( Muntingia calabura ), which exhibit antibacterial properties. This study aimed determine active compound M. extract has potential an agent for S. . The research was conducted September 2022 Universitas Negeri Surabaya. Using PyRx software, we carried out molecular docking (blind docking) analysis. drug-likeness test indicated stigmasterol, tetradecanoic acid, dodecanoic ethyl ester compounds met criteria medicinal compounds. results analysis showed that stigmasterol binding affinity -7.8 kcal/mol better than other RMSD 1.482 Å indicating its high potential. three selected have agents application this product treatment acne, however, requires further research.

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ژورنال

عنوان ژورنال: E3S web of conferences

سال: 2023

ISSN: ['2555-0403', '2267-1242']

DOI: https://doi.org/10.1051/e3sconf/202340002007